Research Team



134. S100B chaperone multimers suppress the formation of oligomers during Aβ42 aggregation
Figueira A.J., Saavedra J., Cardoso I., Gomes C.M.
Frontiers in Neuroscience (2023)

133. Tau liquid–liquid phase separation is modulated by the Ca-switched chaperone activity of the S100B protein
Moreira, G.G., Gomes, C.M.
J Neurochem  (2023)

132. Matrix Metalloproteinases 2 and 9 and Their Tissue Inhibitors in the Diagnostics of Medullary Thyroid Carcinoma
Vázquez-Lorente H., Dundjerović D.M., Tatić S.B., Radojević-Škodrić S., Gomes C.M., Paunović I.R., Dragutinović V.V.
App Immunohistochem & Mol Morph (2023) 31(2)

131. Tetramerization of the S100B Chaperone Spawns a Ca2+ Independent Regulatory Surface that Enhances Anti-aggregation Activity and Client Specificity
Figueira AJ, Moreira GG, Saavedra J, Cardoso I, Gomes CM*
J Mol Biol. (2022) 434(19):167791

130. Relationship between Trace Elements and Matrix Metalloproteinases 2 and 9 and their Tissue Inhibitors in Medullary Thyroid Carcinoma
Vázquez-Lorente, H., Dundjerović, D.M., Tatić, S.B., Rodríguez-Menéndez, S, González-Iglesias, H.,  Gomes, C. M., Paunović, I.R., & Dragutinović, V.V.
Biol Trace Elem Res (2022).
129. Zinc-binding metallophores protect Pseudomonas aeruginosa from calprotectin-mediated metal starvation
Ammendola S, Secli V, Pacello F, Mastropasqua MC, Romão MA, Gomes CM, Battistoni A.
FEMS Microbiol Lett (2022)

128. Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice
Bhatt, D.P., Mills, C.A., Anderson, K.A., Henriques, B.J., Lucas, T.G., Francisco, S., Liu, J., Ilkayeva, O.R., Adams, A.E., Kulkarni, S.R., Backos, D.S., Major, M.B., Grimsrud, P.A., Gomes, C.M., Hirschey, M.D.
J Biol Chem (2022), 101723

127. Dynamic interactions and Ca(II)binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding
Moreira, G.G., Cantrelle, F.-X., Quezada, A., Carvalho, F.S., Cristóvão, J.S., Sengupta, U., Puangmalai, N., Carapeto, A.P., Rodrigues, M.S., Cardoso, I., Fritz, G., Herrera, F., Kayed, R., Landrieu, I., Gomes, C.M*.
Nature Communications (2021) 12, 6292

126. S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis
Daini, E., Hagmeyer, S., De Benedictis, C.A., Cristóvão, J.S., Bodria, M., Ross, A.M., Raab, A., Boeckers, T.M., Feldmann, J., Gomes, C.M., Zoli, M., Vilella, A., Grabrucker, A.M.
Translational psychiatry (2021) 11, 562

125. Hofmeister effects on protein stability are dependent on the nature of the unfolded state
Ribeiro, S.S., Castro, T.G., Gomes, C.M., Marcos, J.C.
Physical Chemistry Chemical Physics (2021) 23, 25210-25225

124. Hypercholesterolemia and 27-Hydroxycholesterol Increase S100A8 and RAGE Expression in the Brain: a Link Between Cholesterol, Alarmins, and Neurodegeneration
Loera-Valencia, R., Ismail, M.A.M., Goikolea, J., Lodeiro, M., Mateos, L., Björkhem, I., Puerta, E., Romão, M.A., Gomes, C.M., Merino-Serrais, P., Maioli, S., Cedazo-Minguez, A.
Molecular Neurobiology (2021) 58, 6063–6076 

123. Electron transfer flavoprotein and its role in mitochondrial energy metabolism in health and disease
Henriques, B.J., Katrine Jentoft Olsen, R., Gomes, C.M., Bross, P.
Gene (2021) 776, 145407

122. Computational Analysis of the Interactions between the S100B Extracellular Chaperone and Its Amyloid β Peptide Client
Rodrigues, F.E.P., Figueira, A.J., Gomes, C.M., Machuqueiro, M.
Int J Mol Sci (2021) 22, 3629

121. Targeting S100B with Peptides Encoding Intrinsic Aggregation-Prone Sequence Segments
Cristóvão, J.S., Romão, M.A., Gallardo, R., Schymkowitz, J., Rousseau, F., Gomes, C.M.
Molecules (2021) 26(2), 440

120. Cu(II)-binding to S100B triggers polymerization of disulfide cross-linked tetramers with enhanced chaperone activity against amyloid-β aggregation
Cristóvão, J.S., Moreira, G.G., Rodrigues, F.E.P., Carapeto, A.P., Rodrigues, M.S., Cardoso, I., Ferreira, A.E.N., Machuqueiro, M., Fritz, G., Gomes, C.M.
Chemical Communications (2021) 57, 379-382

119. Conformational analysis of the riboflavin-responsive ETF:QO-p.Pro456Leu variant associated with mild multiple acyl-CoA dehydrogenase deficiency
Lucas T.G., Henriques B.J., Gomes C.M.
Biochimica et Biophysica Acta - Proteins and Proteomics (2020) 1868(6)

118. Functional Recovery of a GCDH Variant Associated to Severe Deflavinylation-Molecular Insights into Potential Beneficial Effects of Riboflavin Supplementation in Glutaric Aciduria-Type I Patients
Ribeiro, J.V., Gomes, C.M., Henriques, B.J.
Int J Mol Sci (2020) 21,

117. MIRRAGGE – Minimum Information Required for Reproducible AGGregation Experiments
Martins, P.M., Navarro, S., Silva, A., Pinto, M.F., Sárkány, Z., Figueiredo, F., Pereira, P.J.B., Pinheiro, F., Bednarikova, Z., Burdukiewicz, M., Galzitskaya, O.V., Gazova, Z., Gomes, C.M., Pastore, A., Serpell, L.C., Skrabana, R., Smirnovas, V., Ziaunys, M., Otzen, D.E., Ventura, S., Macedo-Ribeiro, S.
Frontiers in Molecular Neuroscience (2020) 13,

116. Glucosylpolyphenols as Inhibitors of Aβ-Induced Fyn Kinase Activation and Tau Phosphorylation: Synthesis, Membrane Permeability, and Exploratory Target Assessment within the Scope of Type 2 Diabetes and Alzheimer’s Disease
de Matos, A.M., Blázquez-Sánchez, M.T., Bento-Oliveira, A., de Almeida, R.F.M., Nunes, R., Lopes, P.E.M., Machuqueiro, M., Cristóvão, J.S., Gomes, C.M., Souza, C.S., El Idrissi, I.G., Colabufo, N.A., Diniz, A., Marcelo, F., Oliveira, M.C., López, Ó., Fernandez-Bolaños, J.G., Dätwyler, P., Ernst, B., Ning, K., Garwood, C., Chen, B., Rauter, A.P.
Journal of medicinal chemistry (2020) 63, 11663-11690

115. The S100B Alarmin Is a Dual-Function Chaperone Suppressing Amyloid-beta Oligomerization through Combined Zinc Chelation and Inhibition of Protein Aggregation
Cristovao, J.S., Figueira, A.J., Carapeto, A.P., Rodrigues, M.S., Cardoso, I., Gomes, C.M.
ACS chemical neuroscience (2020) 11, 2753-2760

Ribeiro J.V., Lucas T.G., Bross P., Gomes C.M., Henriques B.J.
Biochimica et Biophysica Acta - Proteins and Proteomics (2020) 1868(1)

113. Identification of temperature-sensitive mutations and characterization of thermolabile RNase II variants
Reis, F.P., Barria, C., Gomez-Puertas, P., Gomes, C.M., Arraiano, C.M.
FEBS Lett (2019) 593, 352-360

112. Zinc Binding to Tau Influences Aggregation Kinetics and Oligomer Distribution
Moreira, G.G., Cristovao, J.S., Torres, V.M., Carapeto, A.P., Rodrigues, M.S., Landrieu, I., Cordeiro, C., Gomes, C.M.
Int J Mol Sci (2019) 20,

111. Molecular and Clinical Investigations on Portuguese Patients with Multiple acyl-CoA Dehydrogenase Deficiency
Henriques, B.J., Lucas, T.G., Martins, E., Gaspar, A., Bandeira, A., Nogueira, C., Brandao, O., Rocha, H., Vilarinho, L., Gomes, C.M.
Current molecular medicine (2019) 19, 487-493

110. Distribution and Relative Abundance of S100 Proteins in the Brain of the APP23 Alzheimer’s Disease Model Mice
Hagmeyer, S., Romão, M.A., Cristóvão, J.S., Vilella, A., Zoli, M., Gomes, C.M., Grabrucker, A.M.
Frontiers in Neuroscience (2019) 13,

109. S100 Proteins in Alzheimer’s Disease
Cristóvão, J.S., Gomes, C.M.
Frontiers in Neuroscience (2019) 13,

108. Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment.
Santos, G., Barateiro, A., Gomes, C.M., Brites, D., Fernandes, A.
Neuropharmacology (2018) 129, 69-83

107. Zinc binding to S100B affords regulation of trace metal homeostasis and excitotoxicity in the brain
Hagmeyer, S., Cristóvão, J.S., Mulvihill, J.J., Boeckers, T.M., Gomes, C.M., Grabrucker, A.M.
Frontiers in Molecular Neuroscience (2018) 10,

106. The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation
Cristóvão, J.S., Morris, V.K., Cardoso, I., Leal, S.S., Martínez, J., Botelho, H.M., Göbl, C., David, R., Kierdorf, K., Alemi, M., Madl. T., Fritz, G., Reif, B., Gomes, C.M.
Science Advances (2018) 4, eaaq1702

105. Synthesis and effects of flavonoid structure variation on amyloid-β aggregation
Matos, A.M., Cristóvão, J.S., Yashunsky, D.V., Nifantiev, N.E., Viana, A.S., Gomes, C.M., Rauter, A.P.
Pure and Applied Chemistry (2017) 89,

104 Characterization of plasma labile heme in hemolytic conditions
Gouveia, Z., Carlos, A.R., Yuan, X., Aires-da-Silva, F., Stocker, R., Maghzal, G.J., Leal, S.S., Gomes, C.M., Todorovic, S., Iranzo, O., Ramos, S., Santos, A.C., Hamza, I., Gonçalves, J., Soares, M.P.
FEBS Journal (2017) 284, 3278-3301

103. Evidence for synergistic action of transthyretin and IGF-I over the IGF-I receptor
Vieira, M., Leal, S.S., Gomes, C.M., Saraiva, M.J.
Biochim Biophys Acta (2016) 1862, 797-804

102. Free Superoxide is an Intermediate in the Production of H2O2 by Copper(I)-Abeta Peptide and O2
Reybier, K., Ayala, S., Alies, B., Rodrigues, J.V., Bustos Rodriguez, S., La Penna, G., Collin, F., Gomes, C.M., Hureau, C., Faller, P.
Angewandte Chemie (International ed. in English) (2016) 55, 1085-1089

101. Therapeutic Approaches Using Riboflavin in Mitochondrial Energy Metabolism Disorders
Henriques, B.J., Lucas, T.G., Gomes, C.M.
Current drug targets (2016) 17, 1527-1534

100. Metals and Neuronal Metal Binding Proteins Implicated in Alzheimer's Disease
Cristovao, J.S., Santos, R., Gomes, C.M.
Oxid Med Cell Longev (2016) 2016, 9812178

99. Metallothioneins in Prion- and Amyloid-Related Diseases
Adam, P., Krizkova, S., Heger, Z., Babula, P., Pekarik, V., Vaculovicoa, M., Gomes, C.M., Kizek, R., Adam, V.
Journal of Alzheimer's disease : JAD (2016) 51, 637-656

98. Calcium dysregulation links ALS defective proteins and motor neuron selective vulnerability
Leal, S.S., Gomes, C.M.
Frontiers in cellular neuroscience (2015) 9, 225

97. Aberrant zinc binding to immature conformers of metal-free copper-zinc superoxide dismutase triggers amorphous aggregation
Leal, S.S., Cristovao, J.S., Biesemeier, A., Cardoso, I., Gomes, C.M.
Metallomics (2015) 7, 333-346

96. Calcium binding to gatekeeper residues flanking aggregation-prone segments underlies non-fibrillar amyloid traits in superoxide dismutase 1 (SOD1)
Estacio, S.G., Leal, S.S., Cristovao, J.S., Faisca, P.F., Gomes, C.M.
Biochim Biophys Acta (2015) 1854, 118-126

95. On the hunt for truly biocompatible ionic liquids for lipase-catalyzed reactions
Deive, F.J., Ruivo, D., Rodrigues, J.V., Gomes, C.M., Sanroman, M.A., Rebelo, L.P.N., Esperanca, J.M.S.S., Rodriguez, A.
RSC Advances (2015) 5, 3386-3389


94. Structural-functional evaluation of ionic liquid libraries for the design of co-solvents in lipase-catalysed reactions
Rodrigues, J.V., Ruivo, D., Rodriguez, A., Deive, F.J., Esperanca, J.M.S.S., Marrucho, I.M., Gomes, C.M., Rebelo, L.P.N.
Green Chemistry (2014),

93. Ethylmalonic Encephalopathy ETHE1 R163W/R163Q Mutations Alter Protein Stability and Redox Properties of the Iron Centre
Henriques, B.J., Lucas, T.G., Rodrigues, J.V., Frederiksen, J.H., Teixeira, M.S., Tiranti, V., Bross, P., Gomes, C.M.
PloS one (2014) 9, e107157

92. A Conserved Cysteine Residue of Bacillus subtilis SpoIIIJ Is Important for Endospore Development
Corte, L., Valente, F., Serrano, M., Gomes, C.M., Moran, C.P., Jr., Henriques, A.O.
PloS one (2014) 9, e99811

91. Probing the kinetic stabilities of Friedreich's ataxia clinical variants using a solid phase GroEL chaperonin capture platform
Correia, A.R., Naik, S., Fisher, M.T., Gomes, C.M.
Biomolecules (2014) 4, 956-979

90. Biochemical and biophysical characterization of recombinant yeast proteasome maturation factor ump1
Sá-Moura, B., Simões, A.M., Fraga, J., Fernandes, H., Abreu, I.A., Botelho, H.M., Gomes, C.M., Marques, A.J., Dohmen, R.J., Ramos, P.C., Macedo-Ribeiro, S.
Comput Struct Biotechnol J (2013) 7, e201304006

89. Calcium Ions Promote Superoxide Dismutase 1 (SOD1) Aggregation into Non-fibrillar Amyloid: A LINK TO TOXIC EFFECTS OF CALCIUM OVERLOAD IN AMYOTROPHIC LATERAL SCLEROSIS (ALS)?
Leal, S.S., Cardoso, I., Valentine, J.S., Gomes, C.M.
J Biol Chem (2013) 288, 25219-25228

88. Neurodegeneration in Friedreich's Ataxia: From Defective Frataxin to Oxidative Stress
Gomes, C.M., Santos, R.
Oxid Med Cell Longev (2013) 2013, 487534

87. Revertants, Low Temperature, and Correctors Reveal the Mechanism of F508del-CFTR Rescue by VX-809 and Suggest Multiple Agents for Full Correction
Farinha, C.M., King-Underwood, J., Sousa, M., Correia, A.R., Henriques, B.J., Roxo-Rosa, M., Da Paula, A.C., Williams, J., Hirst, S., Gomes, C.M., Amaral, M.D.
Chemistry & Biology (2013) 20, 943-955

86. Small molecules present in the cerebrospinal fluid metabolome influence superoxide dismutase 1 aggregation
Cristovao, J.S., Leal, S.S., Cardoso, I., Gomes, C.M.
Int J Mol Sci (2013) 14, 19128-19145

85. Intrinsically Disordered and Aggregation Prone Regions Underlie beta-Aggregation in S100 Proteins
Carvalho, S.B., Botelho, H.M., Leal, S.S., Cardoso, I., Fritz, G., Gomes, C.M.
PloS one (2013) 8, e76629

84. The sulfur oxygenase reductase from the mesophilic bacterium Halothiobacillus neapolitanus is a highly active thermozyme
Veith, A., Botelho, H.M., Kindinger, F., Gomes, C.M., Kletzin, A.
Journal of bacteriology (2012) 194, 677-685

83. Protein folding modulates the swapped dimerization mechanism of methyl-accepting chemotaxis heme sensors
Silva, M.A., Lucas, T.G., Salgueiro, C.A., Gomes, C.M.
PloS one (2012) 7, e46328

82. Cofactors and metabolites as protein folding helpers in metabolic diseases
Rodrigues, J.V., Henriques, B.J., Lucas, T.G., Gomes, C.M.
Curr Top Med Chem (2012) 12, 2546-2559

81. Mechanism of superoxide and hydrogen peroxide generation by human electron-transfer flavoprotein and pathological variants
Rodrigues, J.V., Gomes, C.M.
Free radical biology & medicine (2012) 53, 12-19

80. Metal ions as modulators of protein conformation and misfolding in neurodegeneration
Leal, S.S., Botelho, H.M., Gomes, C.M.
Coordination Chemistry Reviews (2012) 256, 2253-2270

79. Protein misfolding in disease and small molecule therapies
Gomes, C.M.
Curr Top Med Chem (2012) 12, 2460-2469    

78. S100A6 Amyloid Fibril Formation Is Calcium-modulated and Enhances Superoxide Dismutase-1 (SOD1) Aggregation
Botelho, H.M., Leal, S.S., Cardoso, I., Yanamandra, K., Morozova-Roche, L.A., Fritz, G., Gomes, C.M.
J Biol Chem (2012) 287, 42233-42242

77. Mutations at the flavin binding site of ETF:QO yield a MADD-like severe phenotype in Drosophila
Alves, E., Henriques, B.J., Rodrigues, J.V., Prudencio, P., Rocha, H., Vilarinho, L., Martinho, R.G., Gomes, C.M.
Biochim Biophys Acta (2012) 1822, 1284-1292

76. Protein stability in an ionic liquid milieu: on the use of differential scanning fluorimetry

Rodrigues, J.V., Prosinecki, V., Marrucho, I., Rebelo, L.P., Gomes, C.M.
Physical chemistry chemical physics : PCCP (2011) 13, 13614-13616

75. Cofactors and metabolites as potential stabilizers of mitochondrial acyl-CoA dehydrogenases
Lucas, T.G., Henriques, B.J., Rodrigues, J.V., Bross, P., Gregersen, N., Gomes, C.M.
Biochim Biophys Acta (2011) 1812, 1658-1663

74. A polymorphic position in electron transfer flavoprotein modulates kinetic stability as evidenced by thermal stress
Henriques, B.J., Fisher, M.T., Bross, P., Gomes, C.M.
FEBS Lett (2011) 585, 505-510

73. Structural reorganization renders enhanced metalloprotein stability
Botelho, H.M., Gomes, C.M.
Chem Commun (Camb) (2011) 47, 11149-11151

72. Enhanced superoxide and hydrogen peroxide detection in biological assays
Rodrigues, J.V., Gomes, C.M.
Free radical biology & medicine (2010) 49, 61-66

71. Structural requirements for VAP-B oligomerization and their implication in amyotrophic lateral sclerosis-associated VAP-B(P56S) neurotoxicity
Kim, S., Leal, S.S., Ben Halevy, D., Gomes, C.M., Lev, S.
J Biol Chem (2010) 285, 13839-13849

70. Emerging roles for riboflavin in functional rescue of mitochondrial beta-oxidation flavoenzymes
Henriques, B.J., Olsen, R.K., Bross, P., Gomes, C.M.
Current medicinal chemistry (2010) 17, 3842-3854        

69. Mutational hotspots in electron transfer flavoprotein underlie defective folding and function in multiple acyl-CoA dehydrogenase deficiency
Henriques, B.J., Bross, P., Gomes, C.M.
Biochim Biophys Acta (2010) 1802, 1070-1077

68. Natural and amyloid self-assembly of S100 proteins: structural basis of functional diversity
Fritz, G., Botelho, H.M., Morozova-Roche, L.A., Gomes, C.M.
The FEBS journal (2010) 277, 4578-4590

67. Iron-binding activity in yeast frataxin entails a trade off with stability in the alpha1/beta1 acidic ridge region
Correia, A.R., Wang, T., Craig, E.A., Gomes, C.M.
Biochem J (2010) 426, 197-203

66. Role of a novel disulfide bridge within the all-beta fold of soluble Rieske proteins
Botelho, H.M., Leal, S.S., Veith, A., Prosinecki, V., Bauer, C., Frohlich, R., Kletzin, A., Gomes, C.M.
J Biol Inorg Chem (2010) 15, 271-281

65. No evidence of direct binding between ursodeoxycholic acid and the p53 DNA-binding domain
Amaral, J.D., Correia, A.R., Steer, C.J., Gomes, C.M., Rodrigues, C.M.
Bioscience reports (2010) 30, 359-364

64. Role of flavinylation in a mild variant of multiple acyl-CoA dehydrogenation deficiency: a molecular rationale for the effects of riboflavin supplementation
Henriques, B.J., Rodrigues, J.V., Olsen, R.K., Bross, P., Gomes, C.M.
J Biol Chem (2009) 284, 4222-4229

63. The conserved Trp155 in human frataxin as a hotspot for oxidative stress related chemical modifications
Correia, A.R., Ow, S.Y., Wright, P.C., Gomes, C.M.
Biochem Biophys Res Commun (2009) 390, 1007-1011

62. Metal ions modulate the folding and stability of the tumor suppressor protein S100A2
Botelho, H.M., Koch, M., Fritz, G., Gomes, C.M.
The FEBS journal (2009) 276, 1776-1786

61. The prominent conformational plasticity of lactoperoxidase: a chemical and pH stability analysis
Boscolo, B., Leal, S.S., Salgueiro, C.A., Ghibaudi, E.M., Gomes, C.M.
Biochim Biophys Acta (2009) 1794, 1041-1048

60. A novel type of monoheme cytochrome c: biochemical and structural characterization at 1.23 A resolution of rhodothermus marinus cytochrome c
Stelter, M., Melo, A.M., Pereira, M.M., Gomes, C.M., Hreggvidsson, G.O., Hjorleifsdottir, S., Saraiva, L.M., Teixeira, M., Archer, M.
Biochemistry (2008) 47, 11953-11963

59. Protein misfolding in conformational disorders: rescue of folding defects and chemical chaperoning
Leandro, P., Gomes, C.M.
Mini Rev Med Chem (2008) 8, 901-911

58. On the relative contribution of ionic interactions over iron-sulfur clusters to ferredoxin stability
Leal, S.S., Gomes, C.M.
Biochim Biophys Acta (2008) 1784, 1596-1600

57. Kinetic analysis of L1 homophilic interaction: role of the first four immunoglobulin domains and implications on binding mechanism
Gouveia, R.M., Gomes, C.M., Sousa, M., Alves, P.M., Costa, J.
J Biol Chem (2008) 283, 28038-28047

56. Crystallographic analysis of the intact metal centres [3Fe-4S](1+/0) and [4Fe-4S](2+/1+) in a Zn(2+)-containing ferredoxin
Frazao, C., Aragao, D., Coelho, R., Leal, S.S., Gomes, C.M., Teixeira, M., Carrondo, M.A.
FEBS Lett (2008) 582, 763-767

55. On the relation between native geometry and conformational plasticity
Faisca, P.F., Gomes, C.M.
Biophys Chem (2008) 138, 99-106

54. Dynamics, stability and iron-binding activity of frataxin clinical mutants
Correia, A.R., Pastore, C., Adinolfi, S., Pastore, A., Gomes, C.M.
FEBS journal (2008) 275, 3680-3690

53. A Spectroscopic Study of the Temperature Induced Modifications on Ferredoxin Folding and Iron-Sulfur Moieties
Todorovic, S., Leal, S.S., Salgueiro, C.A., Zebger, I., Hildebrandt, P., Murgida, D.H., Gomes, C.M.
Biochemistry (2007) 46, 10733-10738

52. Conformational states and protein stability in a proteomic perspective.
Prosinecki, V., Faísca, P.F.N., Gomes, C.M.
Current Proteomics (2007) 4, 44-52

51. ApoA-I cleaved by transthyretin has reduced ability to promote cholesterol efflux and increased amyloidogenicity
Liz, M.A., Gomes, C.M., Saraiva, M.J., Sousa, M.M.
J Lipid Res (2007) 48, 2385-2395

50. Studies of the molten globule state of ferredoxin: Structural characterization and implications on protein folding and iron-sulfur center assembly
Leal, S.S., Gomes, C.M.
Proteins (2007) 68, 606-616

49. Lactoperoxidase folding and catalysis relies on the stabilization of the alpha-helix rich core domain: A thermal unfolding study
Boscolo, B., Leal, S.S., Ghibaudi, E.M., Gomes, C.M.
Biochim Biophys Acta (2007) 1774, 1164-1172

48. X-ray Structure of a self-compartmentalizing sulfur cycle metalloenzyme
Urich, T., Gomes, C.M., Kletzin, A., Frazao, C.
Science (2006) 311, 996-1000

47. Natural domain design: enhanced thermal stability of a zinc-lacking ferredoxin isoform shows that a hydrophobic core efficiently replaces the structural metal site
Rocha, R., Leal, S.S., Teixeira, V.H., Regalla, M., Huber, H., Baptista, A.M., Soares, C.M., Gomes, C.M.
Biochemistry (2006) 45, 10376-10384

46. A Proteomic Approach toward the Selection of Proteins with Enhanced Intrinsic Conformational Stability
Prosinecki, V., Botelho, H.M., Francese, S., Mastrobuoni, G., Moneti, G., Urich, T., Kletzin, A., Gomes, C.M.
J Proteome Res (2006) 5, 2720-2726

45. Combined spectroscopic and calorimetric characterisation of rubredoxin reversible thermal transition
Henriques, B.J., Saraiva, L.M., Gomes, C.M.
J Biol Inorg Chem (2006) 11, 73-81

44. Conformational stability of human frataxin and effect of Friedreich's ataxia-related mutations on protein folding
Correia, A.R., Adinolfi, S., Pastore, A., Gomes, C.M.
Biochem J (2006) 398, 605-611

43. Linear three-iron centres are unlikely cluster degradation intermediates during unfolding of iron-sulfur proteins
Leal, S.S., Gomes, C.M.
Biol Chem (2005) 386, 1295-1300

42. A Rieske ferredoxin typifying a subtype within Rieske proteins: spectroscopic, biochemical and stability studies
Kletzin, A., Ferreira, A.S., Hechler, T., Bandeiras, T.M., Teixeira, M., Gomes, C.M.
FEBS Lett (2005) 579, 1020-1026

41. Probing the mechanism of rubredoxin thermal unfolding in the absence of salt bridges by temperature jump experiments
Henriques, B.J., Saraiva, L.M., Gomes, C.M.
Biochem Biophys Res Commun (2005) 333, 839-844

40. The sulphur oxygenase reductase from Acidianus ambivalens is a multimeric protein containing a low-potential mononuclear non-haem iron centre
Urich, T., Bandeiras, T.M., Leal, S.S., Rachel, R., Albrecht, T., Zimmermann, P., Scholz, C., Teixeira, M., Gomes, C.M., Kletzin, A.
Biochem J (2004) 381, 137-146

39. Coupling of the pathway of sulphur oxidation to dioxygen reduction: characterization of a novel membrane-bound thiosulphate:quinone oxidoreductase
Muller, F.H., Bandeiras, T.M., Urich, T., Teixeira, M., Gomes, C.M., Kletzin, A.
Mol Microbiol (2004) 53, 1147-1160

38. Studies on the degradation pathway of iron-sulfur centers during unfolding of a hyperstable ferredoxin: cluster dissociation, iron release and protein stability
Leal, S.S., Teixeira, M., Gomes, C.M.
J Biol Inorg Chem (2004) 9, 987-996

37. Dissimilatory oxidation and reduction of elemental sulfur in thermophilic archaea
Kletzin, A., Urich, T., Muller, F., Bandeiras, T.M., Gomes, C.M.
J Bioenerg Biomembr (2004) 36, 77-91

36. Active site structure of the aa3 quinol oxidase of Acidianus ambivalens
Das, T.K., Gomes, C.M., Bandeiras, T.M., Pereira, M.M., Teixeira, M., Rousseau, D.L.
Biochim Biophys Acta (2004) 1655, 306-320

35. Docking and electron transfer studies between rubredoxin and rubredoxin:oxygen oxidoreductase
Victor, B.L., Vicente, J.B., Rodrigues, R., Oliveira, S., Rodrigues-Pousada, C., Frazao, C., Gomes, C.M., Teixeira, M., Soares, C.M.
J Biol Inorg Chem (2003) 8, 475-488

34. FTIR spectroscopic characterization of the cytochrome aa3 from Acidianus ambivalens: evidence for the involvement of acidic residues in redox coupled proton translocation
Hellwig, P., Gomes, C.M., Teixeira, M.
Biochemistry (2003) 42, 6179-6184

33. The respiratory chain of the thermophilic archaeon Sulfolobus metallicus: studies on the type-II NADH dehydrogenase
Bandeiras, T.M., Salgueiro, C.A., Huber, H., Gomes, C.M., Teixeira, M.
Biochim Biophys Acta (2003) 1557, 13-19

32. Module fusion in an A-type flavoprotein from the cyanobacterium Synechocystis condenses a multiple-component pathway in a single polypeptide chain
Vicente, J.B., Gomes, C.M., Wasserfallen, A., Teixeira, M.
Biochem Biophys Res Commun (2002) 294, 82-87

31. Plasticity of proton pathways in haem-copper oxygen reductases
Pereira, M.M., Gomes, C.M., Teixeira, M.
FEBS Lett (2002) 522, 14-18

30. The quinol:fumarate oxidoreductase from the sulphate reducing bacterium Desulfovibrio gigas: spectroscopic and redox studies
Lemos, R.S., Gomes, C.M., LeGall, J., Xavier, A.V., Teixeira, M.
J Bioenerg Biomembr (2002) 34, 21-30

29. Quinol:fumarate oxidoreductases and succinate:quinone oxidoreductases: phylogenetic relationships, metal centres and membrane attachment
Lemos, R.S., Fernandes, A.S., Pereira, M.M., Gomes, C.M., Teixeira, M.
Biochim Biophys Acta (2002) 1553, 158-170

28. Formation of a linear [3Fe-4S] cluster in a seven-iron ferredoxin triggered by polypeptide unfolding
Jones, K., Gomes, C.M., Huber, H., Teixeira, M., Wittung-Stafshede, P.
J Biol Inorg Chem (2002) 7, 357-362

27. An archaeal b-type cytochrome containing a nonfunctional carbonic anhydrase-like domain
Gomes, C.M., Kletzin, A., Teixeira, M.
J Biol Inorg Chem (2002) 7, 483-489

26. A novel type of nitric-oxide reductase. Escherichia coli flavorubredoxin
Gomes, C.M., Giuffre, A., Forte, E., Vicente, J.B., Saraiva, L.M., Brunori, M., Teixeira, M.
J Biol Chem (2002) 277, 25273-25276 10.1074/jbc.M203886200

25. Functional control of the binuclear metal site in the metallo-beta-lactamase-like fold by subtle amino acid replacements
Gomes, C.M., Frazao, C., Xavier, A.V., Legall, J., Teixeira, M.
Protein Sci (2002) 11, 707-712

24. Acidianus ambivalens type-II NADH dehydrogenase: genetic characterisation and identification of the flavin moiety as FMN
Bandeiras, T.M., Salgueiro, C., Kletzin, A., Gomes, C.M., Teixeira, M.
FEBS Lett (2002) 531, 273-277

23. High stability of a ferredoxin from the hyperthermophilic archaeon A. ambivalens: involvement of electrostatic interactions and cofactors
Moczygemba, C., Guidry, J., Jones, K.L., Gomes, C.M., Teixeira, M., Wittung-Stafshede, P.
Protein Sci (2001) 10, 1539-1548

22. Acidianus ambivalens Complex II typifies a novel family of succinate dehydrogenases
Lemos, R.S., Gomes, C.M., Teixeira, M.
Biochem Biophys Res Commun (2001) 281, 141-150

21. The 'strict' anaerobe Desulfovibrio gigas contains a membrane-bound oxygen-reducing respiratory chain
Lemos, R.S., Gomes, C.M., Santana, M., LeGall, J., Xavier, A.V., Teixeira, M.
FEBS Lett (2001) 496, 40-43

20. Could a diiron-containing four-helix-bundle protein have been a primitive oxygen reductase?
Gomes, C.M., Le Gall, J., Xavier, A.V., Teixeira, M.
Chembiochem (2001) 2, 583-587

19. A new type-II NADH dehydrogenase from the archaeon Acidianus ambivalens: characterization and in vitro reconstitution of the respiratory chain
Gomes, C.M., Bandeiras, T.M., Teixeira, M.
J Bioenerg Biomembr (2001) 33, 1-8

18. Heme-copper oxidases with modified D- and K-pathways are yet efficient proton pumps 
Gomes, C.M., Backgren, C., Teixeira, M., Puustinen, A., Verkhovskaya, M.L., Wikstrom, M., Verkhovsky, M.I.
FEBS Lett (2001) 497, 159-164

17. Kinetics of electron and proton transfer during O(2) reduction in cytochrome aa(3) from A. ambivalens: an enzyme lacking Glu(I-286)
Gilderson, G., Aagaard, A., Gomes, C.M., Adelroth, P., Teixeira, M., Brzezinski, P.
Biochim Biophys Acta (2001) 1503, 261-270

16. Stability and folding of the ferredoxin from the hyperthermophilic archaeon Acidianus ambivalens
Wittung-Stafshede, P., Gomes, C.M., Teixeira, M.
J Inorg Biochem (2000) 78, 35-41

15. Spectroscopic studies and characterization of a novel electron-transfer chain from Escherichia coli involving a flavorubredoxin and its flavoprotein reductase partner
Gomes, C.M., Vicente, J.B., Wasserfallen, A., Teixeira, M.
Biochemistry (2000) 39, 16230-16237

14. Structure of a dioxygen reduction enzyme from Desulfovibrio gigas
Frazao, C., Silva, G., Gomes, C.M., Matias, P., Coelho, R., Sieker, L., Macedo, S., Liu, M.Y., Oliveira, S., Teixeira, M., Xavier, A.V., Rodrigues-Pousada, C., Carrondo, M.A., Le Gall, J.
Nat Struct Biol (2000) 7, 1041-1045

13. Desulfovibrio gigas neelaredoxin. A novel superoxide dismutase integrated in a putative oxygen sensory operon of an anaerobe
Silva, G., Oliveira, S., Gomes, C.M., Pacheco, I., Liu, M.Y., Xavier, A.V., Teixeira, M., Legall, J., Rodrigues-pousada, C.
Eur J Biochem (1999) 259, 235-243

12. The superoxide dismutase activity of desulfoferrodoxin from Desulfovibrio desulfuricans ATCC 27774
Romao, C.V., Liu, M.Y., Le Gall, J., Gomes, C.M., Braga, V., Pacheco, I., Xavier, A.V., Teixeira, M.
Eur J Biochem (1999) 261, 438-443

11. The unusual iron sulfur composition of the Acidianus ambivalens succinate dehydrogenase complex
Gomes, C.M., Lemos, R.S., Teixeira, M., Kletzin, A., Huber, H., Stetter, K.O., Schafer, G., Anemuller, S.
Biochim Biophys Acta (1999) 1411, 134-141

10. Redox-linked transient deprotonation at the binuclear site in the aa(3)-type quinol oxidase from Acidianus ambivalens: implications for proton translocation
Das, T.K., Gomes, C.M., Teixeira, M., Rousseau, D.L.
Proc Natl Acad Sci U S A (1999) 96, 9591-9596 

9. Dynamics of the binuclear center of the quinol oxidase from Acidianus ambivalens
Aagaard, A., Gilderson, G., Gomes, C.M., Teixeira, M., Brzezinski, P.
Biochemistry (1999) 38, 10032-10041

8. Characterisation of a new rubredoxin isolated from Desulfovibrio desulfuricans 27774: definition of a new family of rubredoxins
LeGall, J., Liu, M.Y., Gomes, C.M., Braga, V., Pacheco, I., Regalla, M., Xavier, A.V., Teixeira, M.
FEBS Lett (1998) 429, 295-298

7. Ambineela, an unusual blue protein isolated from the archaeon Acidianus ambivalens
Gomes, C.M., Teixeira, M.
Biochem Biophys Res Commun (1998) 249, 23-25

6. The NADH oxidase from the thermoacidophilic archaea Acidianus ambivalens: isolation and physicochemical characterisation
Gomes, C.M., Teixeira, M.
Biochem Biophys Res Commun (1998) 243, 412-415

5. Evidence for a novel type of iron cluster in the respiratory chain of the archaeon Sulfolobus metallicus
Gomes, C.M., Huber, H., Stetter, K.O., Teixeira, M.
FEBS Lett (1998) 432, 99-102

4. Di-cluster, seven-iron ferredoxins from hyperthermophilic Sulfolobales
Gomes, C.M., Faria, A., Carita, J.C., Mendes, J., Regalla, M., Chicau, P., Huber, H., Stetter, K.O., Teixeira, M.
J Biol Inorg Chem (1998) 3, 499-507

3. Studies on the redox centers of the terminal oxidase from Desulfovibrio gigas and evidence for its interaction with rubredoxin
Gomes, C.M., Silva, G., Oliveira, S., LeGall, J., Liu, M.Y., Xavier, A.V., Rodrigues-Pousada, C., Teixeira, M.
J Biol Chem (1997) 272, 22502-22508

2. Functional properties of the quinol oxidase from Acidianus ambivalens and the possible catalytic role of its electron donor-studies on the membrane-integrated and purified enzyme
Giuffre, A., Gomes, C.M., Antonini, G., D'Itri, E., Teixeira, M., Brunori, M.
Eur J Biochem (1997) 250, 383-388

1.  A seven-iron ferredoxin from the thermoacidophilic archaeon Desulfurolobus ambivalens
Teixeira, M., Batista, R., Campos, A.P., Gomes, C., Mendes, J., Pacheco, I., Anemuller, S., Hagen, W.R.
Eur J Biochem (1995) 227, 322-327


Protein Misfolding and Amyloids in Biomedicine | Faculdade Ciências Universidade de Lisboa
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